Cell cycle: seeking permission from the mother centriole
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Cell cycle: seeking permission from the mother centriole
The key to a successful division of a eukaryotic cell is the assembly of a bipolar mitotic spindle: this allows all chromosomes to attach their kinetochores to opposite poles, and segregate quickly and equally into the two daughter cells. The bipolar spindle axis is ultimately determined by the duplication of the centrosome, an organelle that consists of a pair of centrioles — mother and daught...
متن کاملRevisiting the role of the mother centriole in centriole biogenesis.
Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation. We found that overexpression of SAK/PLK4 could induce amplification of centrioles in Drosophila embryos and their de novo formati...
متن کاملThe centriole duplication cycle.
Centrosomes are the main microtubule-organizing centre of animal cells and are important for many critical cellular and developmental processes from cell polarization to cell division. At the core of the centrosome are centrioles, which recruit pericentriolar material to form the centrosome and act as basal bodies to nucleate formation of cilia and flagella. Defects in centriole structure, func...
متن کاملThe de novo centriole assembly pathway in HeLa cells: cell cycle progression and centriole assembly/maturation
t has been reported that nontransformed mammalian cells become arrested during G 1 in the absence of centrioles (Hinchcliffe, E., F. Miller, M. Cham, A. Khodjakov, and G. Sluder. 2001. Science . 291:1547–1550). Here, we show that removal of resident centrioles (by laser ablation or needle microsurgery) does not impede cell cycle progression in HeLa cells. HeLa cells born without centrosomes, la...
متن کاملCentrosome Biology: A SAS-sy Centriole in the Cell Cycle
A novel protein in Caenorhabditis elegans, SAS-4, is a component of centrioles and is required for centriole duplication. Depletion of SAS-4 results in stunted centrioles and a smaller centrosome, suggesting a link to organelle size control.
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ژورنال
عنوان ژورنال: Current Biology
سال: 2003
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(03)00572-4